Botulism

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Botulism

Botulism is a gradually progressive neuromuscular disease that is associated with a high mortality rate in horses. It is caused by ingestion of the botulinum toxin or Clostridium botulinum spores or it can be absorbed through wound contamination with the bacterium. The toxin is extremely potent, and it acts by interfering with nerve function, resulting in respiratory and musculoskeletal paralysis. There are several different strains of C. botulinum which produce different types of toxins.

Horses are one of the most susceptible animal species to infection with C. botulinum.
Infected horses develop fluctuating muscle weakness and fatigue. Hay can sometimes become contaminated with the bacteria during the raking and baling process. C. botulinum is found worldwide and is commonly found in the environment, inhabiting soil, sewage, and marine sediments, as well as the intestines of decaying carcasses or vegetation. The botulism bacteria grows on food sources which are above a pH of 4.5 and that are in an anaerobic (non-oxygen) environment.

In 2015, there was an outbreak of type-D botulism in 12 horses living in Israel. All of the horses showed clinical signs of progressive weakness, decreased tongue and tail tone, and ataxia. Within 9 days after being infected, 10 out of the 12 horses died, even with supportive care provided.

Symptoms

Progressive weakness
Ataxia
Trembling
Frequently lying down
Decreased tail, anal, eyelid, and tongue tone
Paralysis
Difficulty swallowing
Standing with all four legs close together
Sweating
Lack of appetite

Diagnosis

  • History
  • Clinical signs
  • Physical exam
  • Laboratory tests

Treatment

TherapiesDetails
Botulism antitoxinIf administered early enough and available (as it is not available for use in certain countries)
Intravenous penicillin
Supportive care

Prevention

  • Vaccination
  • Biosecurity

Prognosis

Most cases are fatal.

Scientific Research

General Overviews

Risk Factors

  • Feeding horses large round bales of hay in pastures
  • Feeding horses silage.

Causative agent