Tyzzer's disease

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Tyzzer's Disease

Tyzzer's disease is a sporadic, rapidly progressive, acute and generally fatal hepatitis caused by Clostridium piliforme. C. piliforme has been reported in a wide range of animal species, both wild and domesticated.

Symptoms

Lethargy
Depression
Fever
Jaundice
Loss of appetite
Diarrhea
Seizures/convulsions
Coma
Weakness
Sudden death

Diagnosis

  • Clinical signs
  • Physical exam
  • PCR
  • Postmortem findings

Treatment

TherapiesDetails
Supportive therapy
Antibiotics
Hyperimmune plasma
Pentoxifylline
Oxygen

Prognosis

Poor

Scientific Research

General Overviews

  • Loss of appetite icon

Age Range

Seen most often in foals between the ages of 5 to 36 days of age.

Risk Factors

  • Increase in protein and carbohydrate diet, as it may affect the intestinal microbiome, permitting overgrowth of the pathogenic bacteria.

Causative agent