- Amikacin sulfate is a type of an aminoglycoside antibiotic that comes as an injectable solution (50 mg/ml and 250 mg/ml) to be given IM or SC. The drug has limited activity against gram-positive organisms Pseudomonas and Klebsiella spp that are resistant to other antibiotics.
Aminoglycosides are a group of bactericidal antibiotics, which act by inhibiting bacterial protein synthesis. Their use is restricted because of potential side effects, as they can cause ear and kidney damage. All the aminoglycosides resemble each other in antibacterial activity, pharmacokinetics and toxicity.
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